Description
PT-141 (bremelanotide) is a synthetic peptide that targets melanocortin receptors in the brain to treat sexual dysfunction . Unlike traditional medications like Viagra that increase blood flow, it stimulates the central nervous system to naturally boost libido and arousal.
Mechanism of Action
Unlike drugs that act on the vascular system, PT-141 acts as a melanocortin receptor agonist (specifically MC3R and MC4R). It influences the hypothalamus to directly reignite sexual desire, often referred to as the “ignition” rather than the “fuel”.
Common Uses & Indications
- Hypoactive Sexual Desire Disorder (HSDD): Under the brand name Vyleesi, it is FDA-approved for premenopausal women suffering from low libido not caused by underlying medical or mental health issues.
- Erectile Dysfunction (ED): It is frequently prescribed off-label for men who do not respond to traditional PDE-5 inhibitor medications.
- Note: It does not increase testosterone or alter sex hormones.
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